Protective and Therapeutic Effects of Beta Glucan Administration on Experimental Ulcerative Colitis Model Induced by TNBS

Aim: In this study, it was aimed to investigate the effects of beta glucan (BG) on experimental colitis model created by using trinitrobenzene sulfonic acid (TNBS). Material and Methods: Thirty-two Wistar Albino rats were divided equally into four groups as sham control, TNBS, TNBS-BG3, TNBS-BG10 groups. While saline administrated group, TNBS administered intrarectally under anesthesia. BG at a dose 100 mg/kg oral gavage, intragastrically, for 3 days (TNBS+3) TNBS-BG3 group 10 (7+TNBS+3) group. At end macroscopic, histological biochemical tests applied colon tissues taken. Results: It determined histopathological scoring results that administration caused positive damage due colitis. Malondialdehyde level myeloperoxidase activity found be significantly higher in compared other (p=0.003 p<0.001, respectively). Antioxidant levels increased treated increase statistically significant among glutathione (p<0.001), not catalase enzyme (p=0.218). reduced lipid peroxidation leukocyte infiltration tissue. Positive changes prophylactic effect results. Conclusion: has been show anti-inflammatory antioxidant properties, treatment potential reducing tissue TNBS-induced